Tebanicline– is there hope?

Tebanicline (or ABT-594)

360px-Tebaniciclina

Tebanicline

Tebanicline (or ABT-594)is a medicine developed by Abbott laboratories.  It is derived from epibatidine, a compound isolated from the poison dart frog330px-Blue-poison.dart.frog.and.Yellow-banded.dart.frog.arpTebanicline is 200 times more powerful than morphine in relieving pain– and it is not addictive!  Unfortunately it is reported to cause gastrointestinal side effects in humans.  Nevertheless, it is clear that a new class of pain medications, working through an entirely different neurological system, can be developed.

The principal difficulty in doing this is overcoming the resistance of the powerful pharmaceutical industry who is unlikely to develop non-addictive medicines on their own.  Why should they ruin a system that works to their advantage?

“The observed neuronal selectivity of ABT-594 may contribute to the substantial separation between the antinociceptive efficacy and the reduced cardiovascular side effects of the compound thereby supporting the increased safety index as compared to (±)-epibatidine (Decker et al., in press, 1998). ABT-594 offers the potential of being a novel and safe therapeutic alternative to the limited therapies presently existing for pain management.”  http://jpet.aspetjournals.org/content/285/2/777.full

Also, phasing out opiate pain medicines would have repercussions in the trafficking of illicit drugs as well as in those areas of medicine involved in the treatment of pain and the treatment of addiction.

Again, the opiate pain medicines are a defective product and their use in medical practice must be phased out.